Effects of GAGs in bone and cartilage
- GAG is an important component of extracellular matrix, synovial fluid, and connective tissues
- Excessive GAG levels are detrimental
- GAG accumulation in cartilage affects:
- Bone development1,2
- Formation of epiphyseal plates1–3
- Osteoclast activity3
- Aldenhoven M, et al. Ann Rheum Dis 2009;68:1659–1665.
- Oussoren E, et al. Biochim Biophys Acta 2011;1812(11):1542–1556.
- Clarke LA. Rheumatology 2011;50:v13–v16.
- Scanlon VC. Embryonic growth of bone. In Essentials of Anatomy and Physiology, 6th Ed, 2011.
- White KK. Rheumatology 2011;50:v26–v33.