Neurological
- Mental retardation
- Headaches
- Hydrocephalus
- Spinal cord compression
Visual1
- Corneal clouding
- Glaucoma

Corneal clouding is an early and common sign of MPS disorders in both severe and slowly progressing phenotypes.
Dental1
- Abnormal gums and teeth
- Frequent caries, abscesses

Facial1
- Broad nose
- Flat nasal bridge
- Prominent eyes
- Enlarged tongue and lips
- Prominent forehead
- Macrocephaly
- Coarse hair

Deafness
Chronic Infection
- Pneumonia
- Otitis Media
Cardiovascular
- Valvular heart disease
- Cardiomyopathy
Respiratory
- Obstructive airway diseases
- Obstructive sleep apnea
- Restrictive lung disease
- Recurrent pulmonary infections
Gastrointestinal1
- Hepatomegaly
- Inguinal/umbilical hernias
- Hernia repairs often fail and might need to be repeated
